Insulin resistance and liver histopathology in metabolically unhealthy subjects do not correlate with the hepatic abundance of NLRP3 inflammasome nor circulating IL-1β levels

Insulin resistance and liver histopathology in metabolically unhealthy subjects do not correlate with the hepatic abundance of NLRP3 inflammasome nor circulating IL-1β levels

Introduction Systemic chronic low-grade inflammation has been linked to insulin resistance (IR) and non-alcoholic steatohepatitis (NASH). NOD-like receptor protein 3 (NLRP3) inflammasome and its final product, interleukin (IL)-1β, exert detrimental effects on insulin sensitivity and promote liver in...

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Bibliographic Details
Main Authors: Nicolas Quezada, Ilse Valencia, Javiera Torres, Gregorio Maturana, Jaime Cerda, Juan Pablo Arab, Juan José Fuentes, Claudio Pinto, Dannae Turiel, Victor Cortés
Format: Article
Language:English
Published: BMJ Publishing Group 2021-08-01
Series:BMJ Open Diabetes Research & Care
Online Access:https://drc.bmj.com/content/9/1/e001975.full

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https://drc.bmj.com/content/9/1/e001975.full

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