Target Therapy Using a Small Molecule Inhibitor against Angiogenic Receptors in Pancreatic Cancer

Target Therapy Using a Small Molecule Inhibitor against Angiogenic Receptors in Pancreatic Cancer

PURPOSE: PD173074, a small molecule inhibitor of VEGF-RII and FGF-RI, targets neoangiogenesis and mitogenesis. This study aimed to analyze a singlecompound-driven inhibition of FGF and VEGF receptors in pancreatic cancer. EXPERIMENTAL DESIGN: RT-PCR and Western blots were performed to quantify prot...

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Bibliographic Details
Main Authors: Peter Büchler, Howard A. Reber, Mendel M. Roth, Mark Shiroishi, Helmut Friess, Oscar J. Hines
Format: Article
Language:English
Published: Elsevier 2007-02-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
Angiogenesis
antiangiogenic therapy
pancreatic cancer
tyrosine kinase inhibitors
VEGF receptor
Online Access:http://www.sciencedirect.com/science/article/pii/S147655860780042X

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http://www.sciencedirect.com/science/article/pii/S147655860780042X

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