Systems Genetic Analyses Highlight a TGFβ-FOXO3 Dependent Striatal Astrocyte Network Conserved across Species and Associated with Stress, Sleep, and Huntington's Disease.

Systems Genetic Analyses Highlight a TGFβ-FOXO3 Dependent Striatal Astrocyte Network Conserved across Species and Associated with Stress, Sleep, and Huntington's Disease.

Recent systems-based analyses have demonstrated that sleep and stress traits emerge from shared genetic and transcriptional networks, and clinical work has elucidated the emergence of sleep dysfunction and stress susceptibility as early symptoms of Huntington's disease. Understanding the biolog...

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Bibliographic Details
Main Authors: Joseph R Scarpa, Peng Jiang, Bojan Losic, Ben Readhead, Vance D Gao, Joel T Dudley, Martha H Vitaterna, Fred W Turek, Andrew Kasarskis
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-07-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC4938493?pdf=render

Internet

http://europepmc.org/articles/PMC4938493?pdf=render

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