Structural Basis of the Human Endoglin-BMP9 Interaction: Insights into BMP Signaling and HHT1

Structural Basis of the Human Endoglin-BMP9 Interaction: Insights into BMP Signaling and HHT1

Endoglin (ENG)/CD105 is an essential endothelial cell co-receptor of the transforming growth factor β (TGF-β) superfamily, mutated in hereditary hemorrhagic telangiectasia type 1 (HHT1) and involved in tumor angiogenesis and preeclampsia. Here, we present crystal structures of the ectodomain of huma...

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Bibliographic Details
Main Authors: Takako Saito, Marcel Bokhove, Romina Croci, Sara Zamora-Caballero, Ling Han, Michelle Letarte, Daniele de Sanctis, Luca Jovine
Format: Article
Language:English
Published: Elsevier 2017-05-01
Series:Cell Reports
Subjects:
bone morphogenetic protein receptors
cell surface receptors
endoglin
growth differentiation factor 2
hereditary hemorrhagic telangiectasia
orphan domain
protein interaction domains and motifs
TGF-β superfamily proteins
x-ray crystallography
zona pellucida domain
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717306368

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http://www.sciencedirect.com/science/article/pii/S2211124717306368

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