The glucuronyltransferase B4GAT1 is required for initiation of LARGE-mediated α-dystroglycan functional glycosylation

The glucuronyltransferase B4GAT1 is required for initiation of LARGE-mediated α-dystroglycan functional glycosylation

Dystroglycan is a cell membrane receptor that organizes the basement membrane by binding ligands in the extracellular matrix. Proper glycosylation of the α-dystroglycan (α-DG) subunit is essential for these activities, and lack thereof results in neuromuscular disease. Currently, neither the glycan...

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Bibliographic Details
Main Authors: Tobias Willer, Kei-ichiro Inamori, David Venzke, Corinne Harvey, Greg Morgensen, Yuji Hara, Daniel Beltrán Valero de Bernabé, Liping Yu, Kevin M Wright, Kevin P Campbell
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2014-10-01
Series:eLife
Subjects:
glycosylation
B4GAT1
B3GNT1
LARGE
alpha-dystroglycan
basement membrane
Online Access:https://elifesciences.org/articles/03941

Internet

https://elifesciences.org/articles/03941

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