Selective injury to dopaminergic neurons up-regulates GDNF in substantia nigra postnatal cell cultures: Role of neuron–glia crosstalk

Selective injury to dopaminergic neurons up-regulates GDNF in substantia nigra postnatal cell cultures: Role of neuron–glia crosstalk

The effect of selective injury to dopaminergic neurons on the expression of glial cell line-derived neurotrophic factor (GDNF) was examined in substantia nigra cell cultures. H2O2, mimicking increased oxidative stress, or l-DOPA, the main symptomatic treatment for Parkinson's disease, increased...

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Bibliographic Details
Main Authors: Ana Saavedra, Graça Baltazar, Paulo Santos, Caetana M. Carvalho, Emília P. Duarte
Format: Article
Language:English
Published: Elsevier 2006-09-01
Series:Neurobiology of Disease
Subjects:
Astrocytes
Crosstalk
Dopaminergic neurons
GDNF
Injury
Neuroprotection
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996106000945

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http://www.sciencedirect.com/science/article/pii/S0969996106000945

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