T-2 Toxin Exposure Induces Apoptosis in TM3 Cells by Inhibiting Mammalian Target of Rapamycin/Serine/Threonine Protein Kinase(mTORC2/AKT) to Promote Ca<sup>2+</sup>Production

T-2 Toxin Exposure Induces Apoptosis in TM3 Cells by Inhibiting Mammalian Target of Rapamycin/Serine/Threonine Protein Kinase(mTORC2/AKT) to Promote Ca<sup>2+</sup>Production

Although mTOR (the mammalian target of rapamycin) can regulate intracellular free Ca<sup>2+</sup>concentration in normal cultured podocytes, it remains elusive as to how mTORC2/AKT-mediated Ca<sup>2+</sup>participates in the process of T-2 toxin-induced apoptosis. The potenti...

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Bibliographic Details
Main Authors: Ji Wang, Chenglin Yang, Zhihang Yuan, Jine Yi, Jing Wu
Format: Article
Language:English
Published: MDPI AG 2018-10-01
Series:International Journal of Molecular Sciences
Subjects:
T-2 toxin
apoptosis
TM3 cell
mTOR
AKT
calcium
Online Access:https://www.mdpi.com/1422-0067/19/11/3360

Internet

https://www.mdpi.com/1422-0067/19/11/3360

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