Chlorogenic Acid Targeting of the AKT PH Domain Activates AKT/GSK3β/FOXO1 Signaling and Improves Glucose Metabolism

Chlorogenic Acid Targeting of the AKT PH Domain Activates AKT/GSK3β/FOXO1 Signaling and Improves Glucose Metabolism

Chlorogenic acid (CGA), a bioactive component in the human diet, is reported to exert beneficial effects on the regulation of glucose metabolism. This study was designed to investigate the specific target of CGA, and explore its underlying mechanisms. Beneficial effects of CGA in glucose metabolism...

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Bibliographic Details
Main Authors: Jie Gao, Xin He, Yuejiao Ma, Xuezhi Zhao, Xiaotao Hou, Erwei Hao, Jiagang Deng, Gang Bai
Format: Article
Language:English
Published: MDPI AG 2018-09-01
Series:Nutrients
Subjects:
chlorogenic acid
glucose metabolism
protein kinase B (AKT)
pleckstrin homology (PH) domain
glycogen synthase kinase 3β (GSK3β)
forkhead box O1 (FOXO1)
Online Access:http://www.mdpi.com/2072-6643/10/10/1366

Internet

http://www.mdpi.com/2072-6643/10/10/1366

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