Reevaluation of the role of the multidrug-resistant P-glycoprotein in cellular cholesterol homeostasis

The multidrug resistance P-glycoprotein (P-gp) was recently proposed to redistribute cholesterol in the plasma membrane, suggesting that P-gp could modulate cholesterol efflux to cholesterol acceptors. To address this hypothesis and to reevaluate the role of P-gp in cholesterol homeostasis, we first...

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Bibliographic Details
Main Authors: Wilfried Le Goff, Megan Settle, Diane J. Greene, Richard E. Morton, Jonathan D. Smith
Format: Article
Language:English
Published: Elsevier 2006-01-01
Series:Journal of Lipid Research
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520336543