Reevaluation of the role of the multidrug-resistant P-glycoprotein in cellular cholesterol homeostasis
The multidrug resistance P-glycoprotein (P-gp) was recently proposed to redistribute cholesterol in the plasma membrane, suggesting that P-gp could modulate cholesterol efflux to cholesterol acceptors. To address this hypothesis and to reevaluate the role of P-gp in cholesterol homeostasis, we first...
Main Authors: | Wilfried Le Goff, Megan Settle, Diane J. Greene, Richard E. Morton, Jonathan D. Smith |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2006-01-01
|
Series: | Journal of Lipid Research |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S0022227520336543 |
Similar Items
-
α-Synuclein Regulates Neuronal Cholesterol Efflux
by: Jen-Hsiang T. Hsiao, et al.
Published: (2017-10-01) -
Régulation moléculaire et cellulaire de l'efflux de cholestérol par le transporteur ATP-binding cassette A1(ABCA1)
by: Denis, Maxime
Published: (2016) -
Testing the role of apoA-I, HDL, and cholesterol efflux in the atheroprotective action of low-level apoE expression
by: Fayanne E. Thorngate, et al.
Published: (2003-12-01) -
ABCA1 mutants reveal an interdependency between lipid export function, apoA-I binding activity, and Janus kinase 2 activation
by: Ashley M. Vaughan, et al.
Published: (2009-02-01) -
6-Gingerol Regulates Hepatic Cholesterol Metabolism by Up-regulation of LDLR and Cholesterol Efflux-Related Genes in HepG2 Cells
by: Xiao Li, et al.
Published: (2018-02-01)