Blockade of glycolysis-dependent contraction by oroxylin a via inhibition of lactate dehydrogenase-a in hepatic stellate cells

Blockade of glycolysis-dependent contraction by oroxylin a via inhibition of lactate dehydrogenase-a in hepatic stellate cells

Abstract Background Contraction of hepatic stellate cells (HSCs) plays an important role in the pathogenesis of liver fibrosis by regulating sinusoidal blood flow and extracellular matrix remodeling. Here, we investigated how HSC contraction was affected by the natural compound oroxylin A, and eluci...

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Bibliographic Details
Main Authors: Feixia Wang, Yan Jia, Mengmeng Li, Ling Wang, Jiangjuan Shao, Qinglong Guo, Shanzhong Tan, Hai Ding, Anping Chen, Feng Zhang, Shizhong Zheng
Format: Article
Language:English
Published: BMC 2019-02-01
Series:Cell Communication and Signaling
Subjects:
Liver fibrosis
Oroxylin a
Hepatic stellate cell
Aerobic glycolysis
Contraction
Lactate dehydrogenase-a
Online Access:http://link.springer.com/article/10.1186/s12964-019-0324-8

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http://link.springer.com/article/10.1186/s12964-019-0324-8

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