Interleukin-22 Mediates the Chemotactic Migration of Breast Cancer Cells and Macrophage Infiltration of the Bone Microenvironment by Potentiating S1P/SIPR Signaling

Interleukin-22 Mediates the Chemotactic Migration of Breast Cancer Cells and Macrophage Infiltration of the Bone Microenvironment by Potentiating S1P/SIPR Signaling

The interleukin-22 (IL-22) signaling pathway is well known to be involved in the progression of various cancer types but its role in bone metastatic breast cancer remains unclear. We demonstrate using human GEO profiling that bone metastatic breast cancer displays elevated interleukin-22 receptor 1...

Full description

Bibliographic Details
Main Authors: Eun-Young Kim, Bongkun Choi, Ji-Eun Kim, Si-On Park, Sang-Min Kim, Eun-Ju Chang
Format: Article
Language:English
Published: MDPI AG 2020-01-01
Series:Cells
Subjects:
interleukin 22
breast cancer
il22r1
s1p
s1pr1
metastasis
Online Access:https://www.mdpi.com/2073-4409/9/1/131

Internet

https://www.mdpi.com/2073-4409/9/1/131

Similar Items