Embryonic Expression of NrasG 12 D Leads to Embryonic Lethality and Cardiac Defects

Embryonic Expression of NrasG 12 D Leads to Embryonic Lethality and Cardiac Defects

Ras proteins control a complex intracellular signaling network. Gain-of-function mutations in RAS genes lead to RASopathy disorders in humans, including Noonan syndrome (NS). NS is the second most common syndromic cause of congenital heart disease. Although conditional expression of the NrasG12D/+ m...

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Bibliographic Details
Main Authors: Xiaona You, Myung-Jeom Ryu, Eunjin Cho, Yanzhi Sang, Alisa Damnernsawad, Yun Zhou, Yangang Liu, Jing Zhang, Youngsook Lee
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
Nras mutation
RASopathy
congenital heart defects
fetal liver hematopoiesis
embryonic development
Noonan syndrome
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.633661/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2021.633661/full

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