GSK-3β Inhibition Attenuates LPS-Induced Death but Aggravates Radiation-Induced Death via Down-Regulation of IL-6

GSK-3β Inhibition Attenuates LPS-Induced Death but Aggravates Radiation-Induced Death via Down-Regulation of IL-6

Background: Exposure of high dose ionizing radiation is lethal. Signal pathways involved in radiation biology reaction still remain illdefined. Lipopolysaccharides (LPS), the ligands of Toll-like receptor 4(TLR4), could elicit strong immune responses. Glycogen synthase kinase-3β(GSK-3β) promotes the...

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Bibliographic Details
Main Authors: Bailong Li, Chaoxiong Zhang, Feng He, Wen Liu, Yanyong Yang, Hu Liu, Xin Liu, Jie Wang, Lin Zhang, Bo Deng, Fu Gao, Jianguo Cui, Cong Liu, Jianming Cai
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2013-12-01
Series:Cellular Physiology and Biochemistry
Subjects:
Glycogen synthase kinase-3
LPS
Radiation
IL-6
Online Access:http://www.karger.com/Article/FullText/356606

Internet

http://www.karger.com/Article/FullText/356606

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