Celluar Folding Determinants and Conformational Plasticity of Native C-Reactive Protein

Celluar Folding Determinants and Conformational Plasticity of Native C-Reactive Protein

C-reactive protein (CRP) is an acute phase reactant secreted by hepatocytes as a pentamer. The structure formation of pentameric CRP has been demonstrated to proceed in a stepwise manner in live cells. Here, we further dissect the sequence determinants that underlie the key steps in cellular folding...

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Bibliographic Details
Main Authors: Jian-Min Lv, Jun-Yao Chen, Zu-Pei Liu, Zhen-Yu Yao, Yue-Xin Wu, Cheng-Sen Tong, Bin Cheng
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Immunology
Subjects:
protein folding
disulfide bond
C-reactive protein
inflammation
conformational activation
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00583/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.00583/full

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