IGF1R activation and the in vitro antiproliferative efficacy of IGF1R inhibitor are inversely correlated with IGFBP5 expression in bladder cancer

IGF1R activation and the in vitro antiproliferative efficacy of IGF1R inhibitor are inversely correlated with IGFBP5 expression in bladder cancer

Abstract Background The insulin growth factor (IGF) pathway has been proposed as a potential therapeutic target in bladder cancer. We characterized the expression of components of the IGF pathway — insulin growth factor receptors (INSR, IGF1R, IGF2R), ligands (INS, IGF1, IGF2), and binding proteins...

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Bibliographic Details
Main Authors: Yann Neuzillet, Elodie Chapeaublanc, Clémentine Krucker, Leanne De Koning, Thierry Lebret, François Radvanyi, Isabelle Bernard-Pierrot
Format: Article
Language:English
Published: BMC 2017-09-01
Series:BMC Cancer
Subjects:
Bladder cancer
Oncogenesis
IGF
IGFR
IGFBP
IGF1R inhibitor
Online Access:http://link.springer.com/article/10.1186/s12885-017-3618-5

Internet

http://link.springer.com/article/10.1186/s12885-017-3618-5

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