Structural Basis for Importin-α Binding of the Human Immunodeficiency Virus Tat

Abstract HIV-1 has caused 35 million deaths globally, and approximately the same number is currently living with HIV-1. The trans-activator of transcription (Tat) protein of HIV-1 plays an important regulatory function in the virus life cycle, responsible for regulating the reverse transcription of...

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Bibliographic Details
Main Authors: K. M. Smith, Z. Himiari, S. Tsimbalyuk, J. K. Forwood
Format: Article
Language:English
Published: Nature Publishing Group 2017-05-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-01853-7