Removal of alleles by genome editing (RAGE) against deleterious load
Abstract Background In this paper, we simulate deleterious load in an animal breeding program, and compare the efficiency of genome editing and selection for decreasing it. Deleterious variants can be identified by bioinformatics screening methods that use sequence conservation and biological prior...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | deu |
| Published: |
BMC
2019-04-01
|
| Series: | Genetics Selection Evolution |
| Online Access: | http://link.springer.com/article/10.1186/s12711-019-0456-8 |