An AICD-based functional screen to identify APP metabolism regulators

An AICD-based functional screen to identify APP metabolism regulators

<p>Abstract</p> <p>Background</p> <p>A central event in Alzheimer's disease (AD) is the regulated intramembraneous proteolysis of the β-amyloid precursor protein (APP), to generate the β-amyloid (Aβ) peptide and the APP intracellular domain (AICD). Aβ is the major...

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Main Authors: Lee Jeremy C, O'Connor Michael, Cosentino Christopher P, Patel Shyam A, Sarangi Srikant, Cuellar Trinna L, Chakraborty Ranjita, Khandelwal Preeti J, Zhang Can, Tanzi Rudolph E, Saunders Aleister J
Format: Article
Language:English
Published: BMC 2007-08-01
Series:Molecular Neurodegeneration
Online Access:http://www.molecularneurodegeneration.com/content/2/1/15

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http://www.molecularneurodegeneration.com/content/2/1/15

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