Complement Depletion Improves Human Red Blood Cell Reconstitution in Immunodeficient Mice

Complement Depletion Improves Human Red Blood Cell Reconstitution in Immunodeficient Mice

We have previously shown that human red blood cells (hRBCs) are subject to robust rejection by macrophages in immunodeficient mice. In this study, we found that mouse serum induces hRBC adherence to murine phagocytic cells, including professional phagocytic macrophages and neutrophils and non-profes...

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Bibliographic Details
Main Authors: Bing Chen, Wei Fan, Jun Zou, Siwen Zhang, Jin He, Chang Shu, Guoqing Zhao, Tianmeng Sun, Zheng Hu, Yong-Guang Yang
Format: Article
Language:English
Published: Elsevier 2017-10-01
Series:Stem Cell Reports
Subjects:
red blood cells
erythropoiesis
complement
phagocytes
in vivo
human
immunodeficient mice
humanized mice
opsonization
xenotransplantation
Online Access:http://www.sciencedirect.com/science/article/pii/S2213671117303752

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http://www.sciencedirect.com/science/article/pii/S2213671117303752

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