TLR3 signaling in macrophages is indispensable for the protective immunity of invariant natural killer T cells against enterovirus 71 infection.

TLR3 signaling in macrophages is indispensable for the protective immunity of invariant natural killer T cells against enterovirus 71 infection.

Enterovirus 71 (EV71) is the most virulent pathogen among enteroviruses that cause hand, foot and mouth disease in children but rarely in adults. The mechanisms that determine the age-dependent susceptibility remain largely unclear. Here, we found that the paucity of invariant natural killer T (iNKT...

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Bibliographic Details
Main Authors: Kai Zhu, Juhao Yang, Kaiming Luo, Chunhui Yang, Na Zhang, Ruifeng Xu, Jianxia Chen, Mingfei Jin, Bin Xu, Nining Guo, Jianrong Wang, Zuolong Chen, Ying Cui, Hui Zhao, Yan Wang, Chaoyang Deng, Li Bai, Baoxue Ge, Cheng-Feng Qin, Hao Shen, Chun-Fu Yang, Qibin Leng
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC4304831?pdf=render

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http://europepmc.org/articles/PMC4304831?pdf=render

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