Cytoplasmic retention of a nucleocytoplasmic protein TBC1D3 by microtubule network is required for enhanced EGFR signaling.

Cytoplasmic retention of a nucleocytoplasmic protein TBC1D3 by microtubule network is required for enhanced EGFR signaling.

The hominoid oncogene TBC1D3 enhances epidermal growth factor receptor (EGFR) signaling and induces cell transformation. However, little is known regarding its spatio-temporal regulation and mechanism of tumorigenesis. In the current study, we identified the microtubule subunit β-tubulin as a potent...

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Bibliographic Details
Main Authors: Ze He, Tian Tian, Dan Guo, Huijuan Wu, Yang Chen, Yongchen Zhang, Qing Wan, Huzi Zhao, Congyang Wang, Hongjing Shen, Lei Zhao, Xiaodong Bu, Meiling Wan, Chuanlu Shen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3979746?pdf=render

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http://europepmc.org/articles/PMC3979746?pdf=render

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