Necrostatin-1 Supplementation to Islet Tissue Culture Enhances the In-Vitro Development and Graft Function of Young Porcine Islets

Necrostatin-1 Supplementation to Islet Tissue Culture Enhances the In-Vitro Development and Graft Function of Young Porcine Islets

Pre-weaned porcine islets (PPIs) represent an unlimited source for islet transplantation but are functionally immature. We previously showed that necrostatin-1 (Nec-1) immediately after islet isolation enhanced the in vitro development of PPIs. Here, we examined the impact of Nec-1 on the in vivo fu...

Full description

Bibliographic Details
Main Authors: Hien Lau, Shiri Li, Nicole Corrales, Samuel Rodriguez, Mohammadreza Mohammadi, Michael Alexander, Paul de Vos, Jonathan RT Lakey
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:International Journal of Molecular Sciences
Subjects:
diabetes
xenotransplantation
pig islets
Online Access:https://www.mdpi.com/1422-0067/22/16/8367

Internet

https://www.mdpi.com/1422-0067/22/16/8367

Similar Items