Identifying the ubiquitination targets of E6AP by orthogonal ubiquitin transfer

Identifying the ubiquitination targets of E6AP by orthogonal ubiquitin transfer

E3 ubiquitin ligases regulate biological functions by ubiquitinating defined substrate proteins but overlapping specificities complicate the identification of E3-substrate relationships. Here, the authors construct an orthogonal UB transfer cascade and identify specific substrates of the E3 enzyme E...

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Bibliographic Details
Main Authors: Yiyang Wang, Xianpeng Liu, Li Zhou, Duc Duong, Karan Bhuripanyo, Bo Zhao, Han Zhou, Ruochuan Liu, Yingtao Bi, Hiroaki Kiyokawa, Jun Yin
Format: Article
Language:English
Published: Nature Publishing Group 2017-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-01974-7

Internet

https://doi.org/10.1038/s41467-017-01974-7

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