Allosteric Effects between the Antibody Constant and Variable Regions: A Study of IgA Fc Mutations on Antigen Binding

Allosteric Effects between the Antibody Constant and Variable Regions: A Study of IgA Fc Mutations on Antigen Binding

Therapeutic antibodies have shifted the paradigm of disease treatments from small molecules to biologics, especially in cancer therapy. Despite the increasing number of antibody candidates, much remains unknown about the antibody and how its various regions interact. Recent findings showed that the...

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Bibliographic Details
Main Authors: Chinh Tran-To Su, Wai-Heng Lua, Wei-Li Ling, Samuel Ken-En Gan
Format: Article
Language:English
Published: MDPI AG 2018-06-01
Series:Antibodies
Subjects:
antibody
isotype IgA
Pertuzumab
allosteric
biologics
constant region
variable region
Online Access:http://www.mdpi.com/2073-4468/7/2/20

Internet

http://www.mdpi.com/2073-4468/7/2/20

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