Synaptic Kalirin-7 and Trio Interactomes Reveal a GEF Protein-Dependent Neuroligin-1 Mechanism of Action

Synaptic Kalirin-7 and Trio Interactomes Reveal a GEF Protein-Dependent Neuroligin-1 Mechanism of Action

Summary: The RhoGEFs Kalirin-7 and Trio are regulators of synaptic plasticity, and their dysregulation is associated with a range of neurodevelopmental and neurodegenerative disorders. Although studies have implicated both Kalirin and Trio in certain diseases, such as tauopathies, they remarkably di...

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Bibliographic Details
Main Authors: Jeremiah D. Paskus, Chen Tian, Erin Fingleton, Christine Shen, Xiaobing Chen, Yan Li, Samuel A. Myers, John D. Badger, II, Michael A. Bemben, Bruce E. Herring, Katherine W. Roche
Format: Article
Language:English
Published: Elsevier 2019-12-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124719314482

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http://www.sciencedirect.com/science/article/pii/S2211124719314482

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