Abnormal glutamate homeostasis and impaired synaptic plasticity and learning in a mouse model of tuberous sclerosis complex

Abnormal glutamate homeostasis and impaired synaptic plasticity and learning in a mouse model of tuberous sclerosis complex

Mice with inactivation of the Tuberous sclerosis complex-1 (Tsc1) gene in glia (Tsc1GFAPCKO mice) have deficient astrocyte glutamate transporters and develop seizures, suggesting that abnormal glutamate homeostasis contributes to neurological abnormalities in these mice. We examined the hypothesis t...

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Bibliographic Details
Main Authors: Ling-Hui Zeng, Yannan Ouyang, Vered Gazit, John R. Cirrito, Laura A. Jansen, Kevin C. Ess, Kelvin A. Yamada, David F. Wozniak, David M. Holtzman, David H. Gutmann, Michael Wong
Format: Article
Language:English
Published: Elsevier 2007-11-01
Series:Neurobiology of Disease
Subjects:
Glia
Astrocyte
Glutamate transporter
Microdialysis
Long-term potentiation
Learning
Online Access:http://www.sciencedirect.com/science/article/pii/S096999610700157X

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http://www.sciencedirect.com/science/article/pii/S096999610700157X

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