Syngeneic AAV Pseudo-particles Potentiate Gene Transduction of AAV Vectors

Syngeneic AAV Pseudo-particles Potentiate Gene Transduction of AAV Vectors

Adeno-associated virus (AAV) vectors have emerged as a safe and efficient gene therapy platform. One complication is that a significant amount of empty particles have always been generated as impurities during AAV vector production. However, the effects of such particles on AAV vector performance re...

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Bibliographic Details
Main Authors: Qizhao Wang, Biao Dong, Katie A. Pokiniewski, Jenni Firrman, Zhongren Wu, Mario P.S. Chin, Xiongwen Chen, LinShu Liu, Ruian Xu, Yong Diao, Weidong Xiao
Format: Article
Language:English
Published: Elsevier 2017-03-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
adeno-associated virus
gene therapy
DI particles
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050116301371

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http://www.sciencedirect.com/science/article/pii/S2329050116301371

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