Oral Fc-Coupled Preproinsulin Achieves Systemic and Thymic Delivery Through the Neonatal Fc Receptor and Partially Delays Autoimmune Diabetes

Oral Fc-Coupled Preproinsulin Achieves Systemic and Thymic Delivery Through the Neonatal Fc Receptor and Partially Delays Autoimmune Diabetes

Tolerogenic vaccinations using beta-cell antigens are attractive for type 1 diabetes prevention, but clinical trials have been disappointing. This is probably due to the late timing of intervention, when multiple auto-antibodies are already present. We therefore devised a strategy to introduce the i...

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Bibliographic Details
Main Authors: Noémie Corcos, Slobodan Culina, Claire Deligne, Cassandra Lavaud, Sylvaine You, Roberto Mallone
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Immunology
Subjects:
autoimmunity
immune tolerance
neonatal Fc receptor (FcRn)
type 1 diabetes
preproinsulin
T cells
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.616215/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.616215/full

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