The Yeast Prion [SWI+] Abolishes Multicellular Growth by Triggering Conformational Changes of Multiple Regulators Required for Flocculin Gene Expression

The Yeast Prion [SWI+] Abolishes Multicellular Growth by Triggering Conformational Changes of Multiple Regulators Required for Flocculin Gene Expression

Although transcription factors are prevalent among yeast prion proteins, the role of prion-mediated transcriptional regulation remains elusive. Here, we show that the yeast prion [SWI+] abolishes flocculin (FLO) gene expression and results in a complete loss of multicellularity. Further investigatio...

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Bibliographic Details
Main Authors: Zhiqiang Du, Ying Zhang, Liming Li
Format: Article
Language:English
Published: Elsevier 2015-12-01
Series:Cell Reports
Subjects:
protein-aggregation
amyloids
prion
protein conformation change
Saccharomyces cerevisiae
yeast
Swi1
SWI/SNF
flocculin
filamentous growth
multicellularity
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124715014096

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http://www.sciencedirect.com/science/article/pii/S2211124715014096

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