Identification of Optically Active Pyrimidine Derivatives as Selective 5-HT2C Modulators

Identification of Optically Active Pyrimidine Derivatives as Selective 5-HT2C Modulators

A series of pyrimidine derivatives 4a–i were synthesized and evaluated for their binding affinities towards 5-HT2C receptors. With regard to designed molecules 4a–i, the influence of the size of alkyl ether and the absolute configuration of a stereogenic center on the 5-HT2C binding affinity and sel...

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Bibliographic Details
Main Authors: Juhyeon Kim, Hanbyeol Jo, Hyunseung Lee, Hyunah Choo, Hak Joong Kim, Ae Nim Pae, Yong Seo Cho, Sun-Joon Min
Format: Article
Language:English
Published: MDPI AG 2017-08-01
Series:Molecules
Subjects:
pyrimidine
optically active
enzymatic kinetic resolution
5-HT2C receptor
binding affinity
selectivity
Online Access:https://www.mdpi.com/1420-3049/22/9/1416

Internet

https://www.mdpi.com/1420-3049/22/9/1416

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