HSV-2-driven increase in the expression of α4β7 correlates with increased susceptibility to vaginal SHIV(SF162P3) infection.

HSV-2-driven increase in the expression of α4β7 correlates with increased susceptibility to vaginal SHIV(SF162P3) infection.

The availability of highly susceptible HIV target cells that can rapidly reach the mucosal lymphoid tissues may increase the chances of an otherwise rare transmission event to occur. Expression of α4β7 is required for trafficking of immune cells to gut inductive sites where HIV can expand and it is...

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Bibliographic Details
Main Authors: Diana Goode, Rosaline Truong, Guillermo Villegas, Giulia Calenda, Natalia Guerra-Perez, Michael Piatak, Jeffrey D Lifson, James Blanchard, Agegnehu Gettie, Melissa Robbiani, Elena Martinelli
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-12-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC4270786?pdf=render

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http://europepmc.org/articles/PMC4270786?pdf=render

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