RNase P Ribozymes Inhibit the Replication of Human Cytomegalovirus by Targeting Essential Viral Capsid Proteins

RNase P Ribozymes Inhibit the Replication of Human Cytomegalovirus by Targeting Essential Viral Capsid Proteins

An engineered RNase P-based ribozyme variant, which was generated using the in vitro selection procedure, was used to target the overlapping mRNA region of two proteins essential for human cytomegalovirus (HCMV) replication: capsid assembly protein (AP) and protease (PR). In vitro studies showed tha...

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Bibliographic Details
Main Authors: Zhu Yang, Michael Reeves, Jun Ye, Phong Trang, Li Zhu, Jingxue Sheng, Yu Wang, Ke Zen, Jianguo Wu, Fenyong Liu
Format: Article
Language:English
Published: MDPI AG 2015-06-01
Series:Viruses
Subjects:
gene therapy
ribozyme
RNase P
cytomegalovirus
gene targeting
Online Access:http://www.mdpi.com/1999-4915/7/7/2775

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http://www.mdpi.com/1999-4915/7/7/2775

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