Combined treatment with metformin and gefitinib overcomes primary resistance to EGFR-TKIs with EGFR mutation via targeting IGF-1R signaling pathway

Combined treatment with metformin and gefitinib overcomes primary resistance to EGFR-TKIs with EGFR mutation via targeting IGF-1R signaling pathway

Yong-hong Pan, Lin Jiao, Cai-yu Lin, Cong-hua Lu, Li Li, Heng-yi Chen, Yu-bo Wang, Yong He Department of Respiratory Disease, Daping Hospital, Third Military Medical University, Chongqing 400042, China Aim: Although EGFR tyrosine kinase inhibitors (TKIs) have shown dramatic effects against sensitizi...

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Bibliographic Details
Main Authors: Pan YH, Jiao L, Lin CY, Lu CH, Li L, Chen HY, Wang YB, He Y
Format: Article
Language:English
Published: Dove Medical Press 2018-08-01
Series:Biologics : Targets & Therapy
Subjects:
Metformin
Gefitinib
IGF-1R
primary resistance
Lung cancer
Online Access:https://www.dovepress.com/combined-treatment-with-metformin-and-gefitinib-overcomes-primary-resi-peer-reviewed-article-BTT

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https://www.dovepress.com/combined-treatment-with-metformin-and-gefitinib-overcomes-primary-resi-peer-reviewed-article-BTT

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