p62 Is Required for Stem Cell/Progenitor Retention through Inhibition of IKK/NF-κB/Ccl4 Signaling at the Bone Marrow Macrophage-Osteoblast Niche

p62 Is Required for Stem Cell/Progenitor Retention through Inhibition of IKK/NF-κB/Ccl4 Signaling at the Bone Marrow Macrophage-Osteoblast Niche

In the bone marrow (BM), hematopoietic progenitors (HPs) reside in specific anatomical niches near osteoblasts (Obs), macrophages (MΦs), and other cells forming the BM microenvironment. A connection between immunosurveillance and traffic of HP has been demonstrated, but the regulatory signals that i...

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Bibliographic Details
Main Authors: Kyung Hee Chang, Amitava Sengupta, Ramesh C. Nayak, Angeles Duran, Sang Jun Lee, Ronald G. Pratt, Ashley M. Wellendorf, Sarah E. Hill, Marcus Watkins, Daniel Gonzalez-Nieto, Bruce J. Aronow, Daniel T. Starczynowski, Roberto Civitelli, Maria T. Diaz-Meco, Jorge Moscat, Jose A. Cancelas
Format: Article
Language:English
Published: Elsevier 2014-12-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124714009978

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http://www.sciencedirect.com/science/article/pii/S2211124714009978

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