TFEB deficiency attenuates mitochondrial degradation upon brown adipose tissue whitening at thermoneutrality

TFEB deficiency attenuates mitochondrial degradation upon brown adipose tissue whitening at thermoneutrality

Objective: Brown adipose tissue (BAT) thermogenesis offers the potential to improve metabolic health in mice and humans. However, humans predominantly live under thermoneutral conditions, leading to BAT whitening, a reduction in BAT mitochondrial content and metabolic activity. Recent studies have e...

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Bibliographic Details
Main Authors: Frederike Sass, Christian Schlein, Michelle Y. Jaeckstein, Paul Pertzborn, Michaela Schweizer, Thorsten Schinke, Andrea Ballabio, Ludger Scheja, Joerg Heeren, Alexander W. Fischer
Format: Article
Language:English
Published: Elsevier 2021-05-01
Series:Molecular Metabolism
Subjects:
TFEB
Brown adipose tissue
Whitening
Mitophagy
Thermogenesis
UCP1
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877821000132

Internet

http://www.sciencedirect.com/science/article/pii/S2212877821000132

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