The inhibition of FGF receptor 1 activity mediates sorafenib antiproliferative effects in human malignant pleural mesothelioma tumor-initiating cells

The inhibition of FGF receptor 1 activity mediates sorafenib antiproliferative effects in human malignant pleural mesothelioma tumor-initiating cells

Abstract Background Malignant pleural mesothelioma is an aggressive cancer, characterized by rapid progression and high mortality. Persistence of tumor-initiating cells (TICs, or cancer stem cells) after cytotoxic drug treatment is responsible for tumor relapse, and represents one of the main reason...

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Bibliographic Details
Main Authors: Alessandra Pattarozzi, Elisa Carra, Roberto E. Favoni, Roberto Würth, Daniela Marubbi, Rosa Angela Filiberti, Luciano Mutti, Tullio Florio, Federica Barbieri, Antonio Daga
Format: Article
Language:English
Published: BMC 2017-05-01
Series:Stem Cell Research & Therapy
Subjects:
Pleural mesothelioma
Tumor-initiating cells
Sorafenib
Fibroblast growth factor
Apoptosis
Online Access:http://link.springer.com/article/10.1186/s13287-017-0573-7

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http://link.springer.com/article/10.1186/s13287-017-0573-7

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