Structural myelin defects are associated with low axonal ATP levels but rapid recovery from energy deprivation in a mouse model of spastic paraplegia.

Structural myelin defects are associated with low axonal ATP levels but rapid recovery from energy deprivation in a mouse model of spastic paraplegia.

In several neurodegenerative disorders, axonal pathology may originate from impaired oligodendrocyte-to-axon support of energy substrates. We previously established transgenic mice that allow measuring axonal ATP levels in electrically active optic nerves. Here, we utilize this technique to explore...

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Main Authors: Andrea Trevisiol, Kathrin Kusch, Anna M Steyer, Ingo Gregor, Christos Nardis, Ulrike Winkler, Susanne Köhler, Alejandro Restrepo, Wiebke Möbius, Hauke B Werner, Klaus-Armin Nave, Johannes Hirrlinger
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-11-01
Series:PLoS Biology
Online Access:https://doi.org/10.1371/journal.pbio.3000943

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https://doi.org/10.1371/journal.pbio.3000943

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