PU.1 regulates Alzheimer’s disease-associated genes in primary human microglia

PU.1 regulates Alzheimer’s disease-associated genes in primary human microglia

Abstract Background Microglia play critical roles in the brain during homeostasis and pathological conditions. Understanding the molecular events underpinning microglial functions and activation states will further enable us to target these cells for the treatment of neurological disorders. The tran...

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Bibliographic Details
Main Authors: Justin Rustenhoven, Amy M. Smith, Leon C. Smyth, Deidre Jansson, Emma L. Scotter, Molly E. V. Swanson, Miranda Aalderink, Natacha Coppieters, Pritika Narayan, Renee Handley, Chris Overall, Thomas I. H. Park, Patrick Schweder, Peter Heppner, Maurice A. Curtis, Richard L. M. Faull, Mike Dragunow
Format: Article
Language:English
Published: BMC 2018-08-01
Series:Molecular Neurodegeneration
Subjects:
Alzheimer’s disease
Vorinostat
Phagocytosis
Antigen presentation
Drug screening
Neuroinflammation
Online Access:http://link.springer.com/article/10.1186/s13024-018-0277-1

Internet

http://link.springer.com/article/10.1186/s13024-018-0277-1

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