Negative Symptoms of Schizophrenia and Dopaminergic Transmission: Translational Models and Perspectives Opened by iPSC Techniques

Negative Symptoms of Schizophrenia and Dopaminergic Transmission: Translational Models and Perspectives Opened by iPSC Techniques

Negative symptoms (NS) represent a heterogeneous dimension of schizophrenia (SCZ), associated with a poor functional outcome. A dysregulated dopamine (DA) system, including a reduced D1 receptor activation in the prefrontal cortex, DA hypoactivity in the caudate and alterations in D3 receptor activi...

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Bibliographic Details
Main Authors: Ginetta Collo, Armida Mucci, Giulia M. Giordano, Emilio Merlo Pich, Silvana Galderisi
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Neuroscience
Subjects:
schizophrenia
negative symptoms
dopamine
animal models
iPSC
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2020.00632/full

Internet

https://www.frontiersin.org/article/10.3389/fnins.2020.00632/full

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