In Vitro and In Vivo Short-Term Pulmonary Toxicity of Differently Sized Colloidal Amorphous SiO2

In Vitro and In Vivo Short-Term Pulmonary Toxicity of Differently Sized Colloidal Amorphous SiO2

In vitro prediction of inflammatory lung effects of well-dispersed nanomaterials is challenging. Here, the in vitro effects of four colloidal amorphous SiO2 nanomaterials that differed only by their primary particle size (9, 15, 30, and 55 nm) were analyzed using the rat NR8383 alveolar macrophage (...

Full description

Bibliographic Details
Main Authors: Martin Wiemann, Ursula G. Sauer, Antje Vennemann, Sandra Bäcker, Johannes-Georg Keller, Lan Ma-Hock, Wendel Wohlleben, Robert Landsiedel
Format: Article
Language:English
Published: MDPI AG 2018-03-01
Series:Nanomaterials
Subjects:
alveolar macrophage
short-term inhalation study (STIS)
intratracheal instillation
in vitro cytotoxicity
3R method
dosimetry
TNFα
nanomaterial grouping
regulatory hazard assessment
Online Access:http://www.mdpi.com/2079-4991/8/3/160

Internet

http://www.mdpi.com/2079-4991/8/3/160

Similar Items