Dendritic Cell Migration to Skin-Draining Lymph Nodes Is Controlled by Dermatan Sulfate and Determines Adaptive Immunity Magnitude

Dendritic Cell Migration to Skin-Draining Lymph Nodes Is Controlled by Dermatan Sulfate and Determines Adaptive Immunity Magnitude

For full activation of naïve adaptive lymphocytes in skin-draining lymph nodes (LNs), presentation of peptide:MHC complexes by LN-resident and skin-derived dendritic cells (DCs) that encountered antigens (Ags) is an absolute prerequisite. To get to the nearest draining LN upon intradermal immunizati...

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Bibliographic Details
Main Authors: Reza Nadafi, Jasper J. Koning, Henrike Veninga, Xanthi N. Stachtea, Tanja Konijn, Antonie Zwiers, Anders Malmström, Joke M. M. den Haan, Reina E. Mebius, Marco Maccarana, Rogier M. Reijmers
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-02-01
Series:Frontiers in Immunology
Subjects:
skin–draining lymph node
adaptive immunity
Dse
dendritic cells
dermatan sulfate epimerase
collagen
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00206/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2018.00206/full

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