Interacting with α7 nAChR is a new mechanism for AChE to enhance the inflammatory response in macrophages

Interacting with α7 nAChR is a new mechanism for AChE to enhance the inflammatory response in macrophages

Acetylcholine (ACh) regulates inflammation via α7 nicotinic acetylcholine receptor (α7 nAChR). Acetylcholinesterase (AChE), an enzyme hydrolyzing ACh, is expressed in immune cells suggesting non-classical function in inflammatory responses. Here, the expression of PRiMA-linked G4 AChE was identified...

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Bibliographic Details
Main Authors: Etta Y.L. Liu, Yingjie Xia, Xiangpeng Kong, Maggie S.S. Guo, Anna X.D. Yu, Brody Z.Y. Zheng, Shinghung Mak, Miranda L. Xu, Karl W.K. Tsim
Format: Article
Language:English
Published: Elsevier 2020-10-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Macrophage
AChE
Cholinergic anti-inflammatory pathway
α7 nAChR
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383520305876

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http://www.sciencedirect.com/science/article/pii/S2211383520305876

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