Huangkui Capsule Ameliorates Renal Fibrosis in a Unilateral Ureteral Obstruction Mouse Model Through TRPC6 Dependent Signaling Pathways

Huangkui Capsule Ameliorates Renal Fibrosis in a Unilateral Ureteral Obstruction Mouse Model Through TRPC6 Dependent Signaling Pathways

Renal fibrosis is the final common pathological manifestation of almost all progressive chronic kidney diseases (CKD). Transient receptor potential canonical (TRPC) channels, especially TRPC3/6, were proposed to be essential therapeutic targets for kidney injury. Huangkui capsule (HKC), an important...

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Bibliographic Details
Main Authors: Li-fei Gu, Hai-tao Ge, Lei Zhao, Yu-jing Wang, Fan Zhang, Hai-tao Tang, Zheng-yu Cao, Bo-yang Yu, Cheng-zhi Chai
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Pharmacology
Subjects:
Huangkui capsule
kidney fibrosis
TRPC6
unilateral ureteral obstruction model
TGF-β
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00996/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2020.00996/full

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