Activation of LXRs using the synthetic agonist GW3965 represses the production of pro-inflammatory cytokines by murine mast cells

Activation of LXRs using the synthetic agonist GW3965 represses the production of pro-inflammatory cytokines by murine mast cells

Background: The activation of liver X receptor (LXR) α or LXRβ negatively regulates the expression of pro-inflammatory genes in mammalian cells. We recently reported that 25-hydroxycholesterol, a representative LXR-activating oxysterol, suppresses IL-6 production in mouse mast cells (MCs) following...

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Bibliographic Details
Main Authors: Satoshi Nunomura, Yoshimichi Okayama, Kenji Matsumoto, Noriko Hashimoto, Kaori Endo-Umeda, Tadashi Terui, Makoto Makishima, Chisei Ra
Format: Article
Language:English
Published: Elsevier 2015-09-01
Series:Allergology International
Subjects:
Cell degranulation
Cytokines
IgE receptor
Liver X receptor
Mast cells
Online Access:http://www.sciencedirect.com/science/article/pii/S132389301500074X

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http://www.sciencedirect.com/science/article/pii/S132389301500074X

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