miR-128 Targets the SIRT1/ROS/DR5 Pathway to Sensitize Colorectal Cancer to TRAIL-Induced Apoptosis

Background/Aims: Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is an ideal anti-tumor drug because it exhibits selective cytotoxicity against cancer cells. However, certain cancer cells are resistant to TRAIL, and the potential mechanisms are still unclear. The aim of this study wa...

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Bibliographic Details
Main Authors: Bo Lian, Dongxiang Yang, Yanlong Liu, Gang Shi, Jibin Li, Xiaofei Yan, Keer Jin, Xin Liu, Jianfeng Zhao, Wen Shang, Rui Zhang
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2018-09-01
Series:Cellular Physiology and Biochemistry
Subjects:
ROS
DR5
Online Access:https://www.karger.com/Article/FullText/493818