Setting up a new gold standard: automated temperature-controlled hERG test on Patchliner®
In the present study, the Patchliner® temperature-controlled automated patch clamp system was evaluated for testing actions of drugs on K+ currents through hERG channels expressed in CHO cells at 35-37°C. Obtained IC50 values for a set of reference drugs were matched with those obt...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2012-01-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fphar.2012.00003/full |