HSV-2 Infection of Human Genital Epithelial Cells Upregulates TLR9 Expression Through the SP1/JNK Signaling Pathway

HSV-2 Infection of Human Genital Epithelial Cells Upregulates TLR9 Expression Through the SP1/JNK Signaling Pathway

It is known that herpes simplex virus type 2 (HSV-2) triggers the activation of Toll-like receptor (TLR) 9 signaling pathway and the consequent production of antiviral cytokines in dendritic cells. However, the impact of HSV-2 infection on TLR9 expression and signaling in genital epithelial cells, t...

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Bibliographic Details
Main Authors: Kai Hu, Ming Fu, Jun Wang, Sukun Luo, Mariana Barreto, Rubin Singh, Tasnim Chowdhury, Mei Li, Mudan Zhang, Xinmeng Guan, Juhua Xiao, Qinxue Hu
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Immunology
Subjects:
herpes simplex virus type 2
toll-like receptor 9
genital epithelial cells
specificity protein 1
JNK pathway
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00356/full

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https://www.frontiersin.org/article/10.3389/fimmu.2020.00356/full

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