Liver cancer cell lines distinctly mimic the metabolic gene expression pattern of the corresponding human tumours

Liver cancer cell lines distinctly mimic the metabolic gene expression pattern of the corresponding human tumours

Abstract Background Although metabolism is profoundly altered in human liver cancer, the extent to which experimental models, e.g. cell lines, mimic those alterations is unresolved. Here, we aimed to determine the resemblance of hepatocellular carcinoma (HCC) cell lines to human liver tumours, speci...

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Bibliographic Details
Main Authors: Zeribe C. Nwosu, Nadia Battello, Melanie Rothley, Weronika Piorońska, Barbara Sitek, Matthias P. Ebert, Ute Hofmann, Jonathan Sleeman, Stefan Wölfl, Christoph Meyer, Dominik A. Megger, Steven Dooley
Format: Article
Language:English
Published: BMC 2018-09-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Omics
Tumour metabolism
Well-differentiated
Poorly differentiated
Metabolic vulnerability
Selective therapy
Online Access:http://link.springer.com/article/10.1186/s13046-018-0872-6

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http://link.springer.com/article/10.1186/s13046-018-0872-6

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