Cell Type-Specific Human APP Transgene Expression by Hippocampal Interneurons in the Tg2576 Mouse Model of Alzheimer’s Disease

Cell Type-Specific Human APP Transgene Expression by Hippocampal Interneurons in the Tg2576 Mouse Model of Alzheimer’s Disease

Amyloid precursor protein (APP) transgenic animal models of Alzheimer’s disease have become versatile tools for basic and translational research. However, there is great heterogeneity of histological, biochemical, and functional data between transgenic mouse lines, which might be due to different tr...

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Bibliographic Details
Main Authors: Corinna Höfling, Emira Shehabi, Peer-Hendrik Kuhn, Stefan F. Lichtenthaler, Maike Hartlage-Rübsamen, Steffen Roßner
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-02-01
Series:Frontiers in Neuroscience
Subjects:
Alzheimer’s disease
animal model
amyloid precursor protein
hippocampus
interneuron
calcium-binding proteins
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2019.00137/full

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https://www.frontiersin.org/article/10.3389/fnins.2019.00137/full

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